主要组织相容性复合物HLA

作者：呀yuan- | 来源：互联网 | 2023-09-24 19:39

https:www.genenames.orgdatagenegroup!group588Majorhistocompatibilitycomplex:Themajorhistoc

https://www.genenames.org/data/genegroup/#!/group/588

Major histocompatibility complex: The major histocompatibility complex ( MHC ) is a set of cell surface molecules encoded by a large gene family in all vertebrates. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or body cells. MHC determines compatibility of donors for organ transplant as well as one‘s susceptibility to an autoimmune disease via crossreacting immunization. [Source: Wikipedia]

主要组织相容性复合物：主要组织相容性复合物（MHC）是由所有脊椎动物中的大基因家族编码的一组细胞表面分子。 MHC分子介导白细胞（也称为白血细胞（WBC），其是免疫细胞）与其他白细胞或体细胞的相互作用。 MHC确定供体对器官移植的兼容性以及通过交叉反应免疫接种对自身免疫疾病的易感性。

P01891的定位结构域，由HLA-A基因编码，是该组内的一个示例基因。 [来源：Pfam＆UniProt]

包含44个基因：

HGNC ID (gene)	Approved symbol	Approved name	Previous symbols	Synonyms	Chromosome
HGNC:4931	HLA-A	major histocompatibility complex, class I, A			6p22.1
HGNC:4932	HLA-B	major histocompatibility complex, class I, B	AS		6p21.33
HGNC:4933	HLA-C	major histocompatibility complex, class I, C	HLA-JY3,D6S204,PSORS1		6p21.33
HGNC:4934	HLA-DMA	major histocompatibility complex, class II, DM alpha		D6S222E,RING6	6p21.32
HGNC:4935	HLA-DMB	major histocompatibility complex, class II, DM beta		D6S221E,RING7	6p21.32
HGNC:4936	HLA-DOA	major histocompatibility complex, class II, DO alpha	HLA-DZA,HLA-DNA	HLA-D0-alpha	6p21.32
HGNC:4937	HLA-DOB	major histocompatibility complex, class II, DO beta			6p21.32
HGNC:4938	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	HLA-DP1A		6p21.32
HGNC:4939	HLA-DPA2	major histocompatibility complex, class II, DP alpha 2 (pseudogene)	HLA-DP2A		6p21.32
HGNC:19393	HLA-DPA3	major histocompatibility complex, class II, DP alpha 3 (pseudogene)			6p21.32
HGNC:4940	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	HLA-DP1B		6p21.32
HGNC:4941	HLA-DPB2	major histocompatibility complex, class II, DP beta 2 (pseudogene)	HLA-DP2B	DP2B,DPB2	6p21.32
HGNC:4942	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	HLA-DQA	CELIAC1	6p21.32
HGNC:4943	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	HLA-DXA		6p21.32
HGNC:4944	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	HLA-DQB	IDDM1,CELIAC1	6p21.32
HGNC:4945	HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	HLA-DXB		6p21.32
HGNC:4946	HLA-DQB3	major histocompatibility complex, class II, DQ beta 3	HLA-DVB	D6S205,D6S205E,DVB,DQB3	6p21.3
HGNC:4947	HLA-DRA	major histocompatibility complex, class II, DR alpha	HLA-DRA1		6p21.32
HGNC:4948	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	HLA-DR1B		6p21.32
HGNC:4950	HLA-DRB2	major histocompatibility complex, class II, DR beta 2 (pseudogene)	HLA-DR2B		6p21.3 alternate reference locus
HGNC:4951	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	HLA-DR3B		6p21.3 alternate reference locus
HGNC:4952	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	HLA-DR4B		6p21.3 alternate reference locus
HGNC:4953	HLA-DRB5	major histocompatibility complex, class II, DR beta 5			6p21.32
HGNC:4954	HLA-DRB6	major histocompatibility complex, class II, DR beta 6 (pseudogene)			6p21.32
HGNC:4955	HLA-DRB7	major histocompatibility complex, class II, DR beta 7 (pseudogene)			6p21.3 alternate reference locus
HGNC:4956	HLA-DRB8	major histocompatibility complex, class II, DR beta 8 (pseudogene)			6p21.3 alternate reference locus
HGNC:4957	HLA-DRB9	major histocompatibility complex, class II, DR beta 9 (pseudogene)	HLA-DRB1L,HLA-DR1BL	D6S206,D6S206E	6p21.32
HGNC:4962	HLA-E	major histocompatibility complex, class I, E			6p22.1
HGNC:4963	HLA-F	major histocompatibility complex, class I, F			6p22.1
HGNC:4964	HLA-G	major histocompatibility complex, class I, G			6p22.1
HGNC:4965	HLA-H	major histocompatibility complex, class I, H (pseudogene)			6p22.1
HGNC:4967	HLA-J	major histocompatibility complex, class I, J (pseudogene)	HLA-CDA12,D6S203	CDA12,HLA-59	6p22.1
HGNC:4969	HLA-K	major histocompatibility complex, class I, K (pseudogene)	HLAK,HLA70	HLA-70	6p22.1
HGNC:4970	HLA-L	major histocompatibility complex, class I, L (pseudogene)	HLA92,HLAL	HLA-92	6p22.1
HGNC:19406	HLA-N	major histocompatibility complex, class I, N (pseudogene)		HLA-30	6p22.1
HGNC:21196	HLA-P	major histocompatibility complex, class I, P (pseudogene)	C6orf101,HLA-90	dJ377H14.3	6p22.1
HGNC:19395	HLA-S	major histocompatibility complex, class I, S (pseudogene)		HLA-17	6p21.33
HGNC:23478	HLA-T	major histocompatibility complex, class I, T (pseudogene)	HLA-16		6p22.1
HGNC:23477	HLA-U	major histocompatibility complex, class I, U (pseudogene)	HLA-21	Em:AB023056.13	6p22.1
HGNC:23482	HLA-V	major histocompatibility complex, class I, V (pseudogene)	HLA-75	dJ377H14.4	6p22.1
HGNC:23425	HLA-W	major histocompatibility complex, class I, W (pseudogene)	HLA-80		6p22.1
HGNC:19385	HLA-X	major histocompatibility complex, class I, X (pseudogene)			6p21.3
HGNC:33913	HLA-Y	major histocompatibility complex, class I, Y (pseudogene)		HLA-BEL/COQ/DEL	6p21.33
HGNC:19394	HLA-Z	major histocompatibility complex, class I, Z (pseudogene)		HLA-Z1	6p21.32

详细信息：

HGNC ID	Approved symbol	Approved name	Status	Locus type	Previous symbols	Synonyms	Chromosome	NCBI Gene ID	Ensembl gene ID	Vega gene ID	Group ID	Group name
HGNC:4931	HLA-A	major histocompatibility complex, class I, A	Approved	gene with protein product			6p22.1	3105	ENSG00000206503	OTTHUMG00000130501	588	Histocompatibility complex
HGNC:4932	HLA-B	major histocompatibility complex, class I, B	Approved	gene with protein product	AS		6p21.33	3106	ENSG00000234745	OTTHUMG00000031153	588	Histocompatibility complex
HGNC:4933	HLA-C	major histocompatibility complex, class I, C	Approved	gene with protein product	HLA-JY3, D6S204, PSORS1		6p21.33	3107	ENSG00000204525	OTTHUMG00000031154	588	Histocompatibility complex
HGNC:4934	HLA-DMA	major histocompatibility complex, class II, DM alpha	Approved	gene with protein product		D6S222E, RING6	6p21.32	3108	ENSG00000204257	OTTHUMG00000031173	588	Histocompatibility complex
HGNC:4935	HLA-DMB	major histocompatibility complex, class II, DM beta	Approved	gene with protein product		D6S221E, RING7	6p21.32	3109	ENSG00000242574	OTTHUMG00000031176	588	Histocompatibility complex
HGNC:4936	HLA-DOA	major histocompatibility complex, class II, DO alpha	Approved	gene with protein product	HLA-DZA, HLA-DNA	HLA-D0-alpha	6p21.32	3111	ENSG00000204252	OTTHUMG00000031211	588	Histocompatibility complex
HGNC:4937	HLA-DOB	major histocompatibility complex, class II, DO beta	Approved	gene with protein product			6p21.32	3112	ENSG00000241106	OTTHUMG00000031213	588	Histocompatibility complex
HGNC:4938	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	Approved	gene with protein product	HLA-DP1A		6p21.32	3113	ENSG00000231389	OTTHUMG00000031058	588	Histocompatibility complex
HGNC:4939	HLA-DPA2	major histocompatibility complex, class II, DP alpha 2 (pseudogene)	Approved	pseudogene	HLA-DP2A		6p21.32	646702	ENSG00000231461	OTTHUMG00000031061	588	Histocompatibility complex
HGNC:19393	HLA-DPA3	major histocompatibility complex, class II, DP alpha 3 (pseudogene)	Approved	pseudogene			6p21.32	267013	ENSG00000237398	OTTHUMG00000031063	588	Histocompatibility complex
HGNC:4940	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	Approved	gene with protein product	HLA-DP1B		6p21.32	3115	ENSG00000223865	OTTHUMG00000031076	588	Histocompatibility complex
HGNC:4941	HLA-DPB2	major histocompatibility complex, class II, DP beta 2 (pseudogene)	Approved	pseudogene	HLA-DP2B	DP2B, DPB2	6p21.32	3116	ENSG00000224557	OTTHUMG00000031080	588	Histocompatibility complex
HGNC:4942	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	Approved	gene with protein product	HLA-DQA	CELIAC1	6p21.32	3117	ENSG00000196735	OTTHUMG00000031106	588	Histocompatibility complex
HGNC:4943	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	Approved	gene with protein product	HLA-DXA		6p21.32	3118	ENSG00000237541	OTTHUMG00000031108	588	Histocompatibility complex
HGNC:4944	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	Approved	gene with protein product	HLA-DQB	IDDM1, CELIAC1	6p21.32	3119	ENSG00000179344	OTTHUMG00000031124	588	Histocompatibility complex
HGNC:4945	HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	Approved	gene with protein product	HLA-DXB		6p21.32	3120	ENSG00000232629	OTTHUMG00000031125	588	Histocompatibility complex
HGNC:4946	HLA-DQB3	major histocompatibility complex, class II, DQ beta 3	Approved	unknown	HLA-DVB	D6S205, D6S205E, DVB, DQB3	6p21.3	3121	ENSG00000226030	OTTHUMG00000031127	588	Histocompatibility complex
HGNC:4947	HLA-DRA	major histocompatibility complex, class II, DR alpha	Approved	gene with protein product	HLA-DRA1		6p21.32	3122	ENSG00000204287	OTTHUMG00000031269	588	Histocompatibility complex
HGNC:4948	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	Approved	gene with protein product	HLA-DR1B		6p21.32	3123	ENSG00000196126	OTTHUMG00000031196	588	Histocompatibility complex
HGNC:4950	HLA-DRB2	major histocompatibility complex, class II, DR beta 2 (pseudogene)	Approved	pseudogene	HLA-DR2B		6p21.3 alternate reference locus	3124	ENSG00000227442	OTTHUMG00000012608	588	Histocompatibility complex
HGNC:4951	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	Approved	gene with protein product	HLA-DR3B		6p21.3 alternate reference locus	3125	ENSG00000196101	OTTHUMG00000012609	588	Histocompatibility complex
HGNC:4952	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	Approved	gene with protein product	HLA-DR4B		6p21.3 alternate reference locus	3126	ENSG00000227357	OTTHUMG00000138996	588	Histocompatibility complex
HGNC:4953	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	Approved	gene with protein product			6p21.32	3127	ENSG00000198502	OTTHUMG00000031027	588	Histocompatibility complex
HGNC:4954	HLA-DRB6	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Approved	pseudogene			6p21.32	3128	ENSG00000229391	OTTHUMG00000031028	588	Histocompatibility complex
HGNC:4955	HLA-DRB7	major histocompatibility complex, class II, DR beta 7 (pseudogene)	Approved	pseudogene			6p21.3 alternate reference locus	3129	ENSG00000227099	OTTHUMG00000139002	588	Histocompatibility complex
HGNC:4956	HLA-DRB8	major histocompatibility complex, class II, DR beta 8 (pseudogene)	Approved	pseudogene			6p21.3 alternate reference locus	3130	ENSG00000233697	OTTHUMG00000138997	588	Histocompatibility complex
HGNC:4957	HLA-DRB9	major histocompatibility complex, class II, DR beta 9 (pseudogene)	Approved	pseudogene	HLA-DRB1L, HLA-DR1BL	D6S206, D6S206E	6p21.32	3132	ENSG00000196301	OTTHUMG00000031197	588	Histocompatibility complex
HGNC:4962	HLA-E	major histocompatibility complex, class I, E	Approved	gene with protein product			6p22.1	3133	ENSG00000204592	OTTHUMG00000031155	588	Histocompatibility complex
HGNC:4963	HLA-F	major histocompatibility complex, class I, F	Approved	gene with protein product			6p22.1	3134	ENSG00000204642	OTTHUMG00000031156	588	Histocompatibility complex
HGNC:4964	HLA-G	major histocompatibility complex, class I, G	Approved	gene with protein product			6p22.1	3135	ENSG00000204632	OTTHUMG00000031157	588	Histocompatibility complex
HGNC:4965	HLA-H	major histocompatibility complex, class I, H (pseudogene)	Approved	pseudogene			6p22.1	3136	ENSG00000206341	OTTHUMG00000031160	588	Histocompatibility complex
HGNC:4967	HLA-J	major histocompatibility complex, class I, J (pseudogene)	Approved	pseudogene	HLA-CDA12, D6S203	CDA12, HLA-59	6p22.1	3137	ENSG00000204622	OTTHUMG00000031161	588	Histocompatibility complex
HGNC:4969	HLA-K	major histocompatibility complex, class I, K (pseudogene)	Approved	pseudogene	HLAK, HLA70	HLA-70	6p22.1	3138	ENSG00000230795	OTTHUMG00000031162	588	Histocompatibility complex
HGNC:4970	HLA-L	major histocompatibility complex, class I, L (pseudogene)	Approved	pseudogene	HLA92, HLAL	HLA-92	6p22.1	3139	ENSG00000243753	OTTHUMG00000031164	588	Histocompatibility complex
HGNC:19406	HLA-N	major histocompatibility complex, class I, N (pseudogene)	Approved	pseudogene		HLA-30	6p22.1	267014	ENSG00000224372	OTTHUMG00000031167	588	Histocompatibility complex
HGNC:21196	HLA-P	major histocompatibility complex, class I, P (pseudogene)	Approved	pseudogene	C6orf101, HLA-90	dJ377H14.3	6p22.1	352963	ENSG00000261548	OTTHUMG00000172781	588	Histocompatibility complex
HGNC:19395	HLA-S	major histocompatibility complex, class I, S (pseudogene)	Approved	pseudogene		HLA-17	6p21.33	267015	ENSG00000225851	OTTHUMG00000031178	588	Histocompatibility complex
HGNC:23478	HLA-T	major histocompatibility complex, class I, T (pseudogene)	Approved	pseudogene	HLA-16		6p22.1	352964	ENSG00000231130	OTTHUMG00000031232	588	Histocompatibility complex
HGNC:23477	HLA-U	major histocompatibility complex, class I, U (pseudogene)	Approved	pseudogene	HLA-21	Em:AB023056.13	6p22.1	352965	ENSG00000228078	OTTHUMG00000031245	588	Histocompatibility complex
HGNC:23482	HLA-V	major histocompatibility complex, class I, V (pseudogene)	Approved	pseudogene	HLA-75	dJ377H14.4	6p22.1	352962	ENSG00000181126	OTTHUMG00000031277	588	Histocompatibility complex
HGNC:23425	HLA-W	major histocompatibility complex, class I, W (pseudogene)	Approved	pseudogene	HLA-80		6p22.1	352966	ENSG00000235290	OTTHUMG00000031242	588	Histocompatibility complex
HGNC:19385	HLA-X	major histocompatibility complex, class I, X (pseudogene)	Approved	pseudogene			6p21.3	267016			588	Histocompatibility complex
HGNC:33913	HLA-Y	major histocompatibility complex, class I, Y (pseudogene)	Approved	pseudogene		HLA-BEL/COQ/DEL	6p21.33	100127173			588	Histocompatibility complex
HGNC:19394	HLA-Z	major histocompatibility complex, class I, Z (pseudogene)	Approved	pseudogene		HLA-Z1	6p21.32	267017	ENSG00000235301	OTTHUMG00000031189	588	Histocompatibility complex

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